The through-wall design of pharmaceutical equipment refers to the layout of passing part of the equipment through the partition wall to another room in order to save the area of the process area. Or the parts or devices of the contact part of the equipment and the drug are placed in the process area of high cleanliness grade, and the transmission, control and maintenance positions of the equipment are set in the auxiliary area, and the layout method of ensuring the isolation of two different clean areas through engineering technical measures.
(I) save the cost of plant use
Pharmaceutical production has strict requirements on the production environment, without affecting the production process and operation, reducing the clean area can reduce environmental costs. The equipment adopts through-wall design, and the process area occupied by the equipment itself is about the cost of the plant.
(II) facilitate self-cleaning of plant and equipment
Traditional design of pharmaceutical equipment due to maintenance needs, covers and other covers need to be made detachable, not easy to seal processing. Because the through-wall pharmaceutical equipment is close to the side of the high-grade clean area, it does not need to be disassembled after installation, so it can be designed as a fixed or integral type, reducing the joint treatment, making the appearance of the equipment clean and tidy, and easy to realize the purification treatment of the process area, such as cleaning and disinfection.
The design and manufacture of the (III) equipment itself can be optimized
regular design of the equipment, due to component rust, transmission part of the lubricating oil leakage, pulley and belt friction debris or the necessary access door settings may cause pollution of the process area. After strict isolation measures are taken between the process area and the auxiliary area of the equipment with through-wall layout, the above problems can be placed in the auxiliary area, and the design of the process area can make the equipment meet the requirements of cleanliness, and can also solve the problems of strength, transmission, heat dissipation and cost of the traditional design, thus optimizing the equipment design and meeting the GMP requirements.
(IV) reduces noise and improves the comfort of the working environment
The transmission equipment is placed in the auxiliary area, and then through isolation measures, the transmission noise can be reduced, which is conducive to improving the comfort of the working environment.
(V) to facilitate equipment operation
The through-wall layout can consider installing the touch screen and other operation interfaces through the wall, which does not occupy the space of the process area and is convenient for the use and cleaning of the operation interface.
(VI) for easy maintenance
The overall design of the through-wall layout workshop can concentrate the auxiliary areas of various equipment. On the one hand, it can shorten the water, electricity, gas, steam and other pipelines provided by the factory, facilitate the maintenance of the delivery room facilities, and reduce the operating cost of the factory; On the other hand, the special maintenance area designed for pharmaceutical equipment can facilitate the docking installation of water, electricity, gas, steam and equipment, thus bringing convenience to the overall maintenance of equipment and workshop.
(VII) maintenance work does not affect the process area
After the main device is isolated, the maintenance work is carried out in the maintenance area to prevent the clean areas of different grades from communicating during the maintenance operation, so that the cleanliness level is damaged. Here, through-the-wall layout can realize maintenance without affecting the production of other equipment, and ensure that maintenance activities do not affect the quality of drugs to the greatest extent, in line with GMP requirements.
